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In addition to the glucoregulatory and central appetite-suppressive effects of GLP-1 receptor agonists, this drug class also exhibit gastrointestinal effects by inhibiting gastric emptying as well as having intestinotrophic and gut immunomodulatory properties 18,19,20,21,22

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Key points Increased intestinal permeability occurs in a wide range of disorders, including inflammatory bowel disease, coeliac disease and graft-versus-host disease, but the relative contributions of barrier dysfunction and immune responses are unclear

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