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have indicated that exposure of leukocytes to MGO changes their morphology by making them larger and more granular, increases their ability to produce ROS and decreases their expression of antioxidant genes (124)

ROS also promotes osteoclast differentiation through multiple pathways, including MAPK, IP3, and NFkB [18], leading to osteoclast maturation via activation of genes like NFATC1 [19]

Therefore, 23 clinical studies published from 2020 to 2025 are presented from various countries that examined oral collagen supplementation in women who were aged 30 to over 65 years (Table 1)

This extended activity allows for more flexibility in dosing, though it is still commonly used at night or post-workout