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The 1 H-NMR spectra showed the disappearance of the doublet signals corresponding to the -lactam ring protons (H5 and H6) of AX at 5.39 and 5.35 ppm (J 5,6 = 3.9 Hz), and their appearance at 4.02 and 5.17 ppm (J 5,6 = 2.6 Hz) ( Figure 2C )

26 Therefore, we suggest that hypertensive individuals with the 718C variant of the GPX4 gene are susceptible to CS because of the increased concentration or activity of the enzyme promoting proinflammatory processes and increasing the brain injury