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Dark patches are caused by several reasons: Sun exposure increased UV light causes an increase in melanin, and resulting hyperpigmentation Hormonal influences commonly causes melasma and skin hyperpigmentation in women Chemicals chemical irritants can cause pigmentation and discoloration on the skin Acne breakouts after an acne flare, the skin may become discolored, called post-inflammatory hyperpigmentation (PIH), which appears almost as acne scars

Authors: Jianjun Cao, Matthew J

Vitamin B12 Injections B12 Injections Vitamin B12 is an essential nutrient that plays an important role in energy production, red blood cell formation, nerve function, and overall wellness

Figures S4 and S5 show networks of routes of administration for secondary outcomes