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doi: 10.3389/fendo.2025.1663499 Received 10 July 2025 Accepted 22 August 2025 Published 19 September 2025 Volume 16 - 2025 Edited by George Paltoglou, National and Kapodistrian University of Athens, Greece Reviewed by Fahad S

Although the most common neoplasms seen in patients with NF1 are benign neurofibromas, MPNSTs are the most common malignant neoplasm in this population, occurring in approximately 10% of patients with NF1 [16]

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Chr 11qB(1.2) locus comprises Gm5431 with genes Irgm1, Tgtp1, Tgtp2, Ifi47 and uncharacterized genes 9930111J21Rik1, 9930111J21Rik2, Gm12185, Gm12186 and Gm12187 (and their transcribed isoforms) ( Figure 8A , Supplementary Data 5)