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In some cases, blood clots have occurred (again, this is typically with a very high dosage, and it is possibly a complication of other medical conditions, or other medications which interact adversely with the B12)

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Compared to the placebo lotion, a ten-week application of 2% oxidized glutathione lotion (GSSG) significantly decreased pigmentation and wrinkling and improved skin moisture and smoothness in the participating women

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