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Several subclasses of these former T-regs have been identified in the atherosclerotic lesions of mice, including Th1-Tregs (CD4 + CCR5 + IFN- + FoxP3 + T-bet + ) and T follicular helper cells (CXCR5 + PD1 + Bcl6 + CD62L lo CD44 hi CD4 + Foxp3 - ), and these have been shown to have both impaired regulatory and enhanced inflammatory function, therefore contributing to atheroprogression (91,92)

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While lipid- and DHA-conjugated forms tend to outperform free AST in cognitive improvement and plaque reduction, no standardized regimen exists, making comparisons across studies difficult

However, oxidative stress can occur also in compatible plant-bacterium interactions