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It must have the strength to transmit 20% of the load of the carpus to the ulna and to stabilize the DRUJ and ulnar carpus in conjunction with the bony architecture of the sigmoid notch

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While some polyphenol-rich extracts, such as grape seed extract, have shown high tolerability in animal and short-term human studies, the safety of long-term, high-dose intake across a broad population spectrum remains to be confirmed (122, 123)

References for Life History Altig, Ronald & McDiarmid, Roy W