reddit switching from semaglutide to tirzepatide changing from Semaglutide to Tirzepatide: Is It a Good Idea? Switching to Tirzepatide : r/Semaglutide

Plasma semaglutide concentrations were similar in dogs undergoing pyloric ligation (to prevent intestinal absorption) compared to non-ligated dogs, with plasma concentrations in the splenic vein being significantly higher than in the portal vein, providing further evidence that the stomach is the site of absorption

The action of GIP in the brain, however, also involves a decrease in appetite circuits but paradoxically would have an anti-nausea effect

Heres a quick look at how they stack up: The fundamental difference lies in tirzepatide's dual-receptor activity

The sweet spot is roughly a hand width above the knee and a hand width below the hip, along the outer edge of the leg