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We proposed that the lysosomal membrane itself might be the missing link that orchestrates the AND gate and compensates for the more-than-two orders of magnitude in concentration needed for RHEBGTP activation of mTORC1
Just to give few examples, buformin and phenformin were showed to inhibit the viability of pituitary cancer cells in vitro (Vzquez-Borrego et al., 2019)
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