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The Phase 2 NEJM trial showed 24.2% average body weight reduction at 48 weeks in the 12mg group

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Key RTKs in eye include VEGF receptors (VEGFR1, VEGFR2, VEGFR3) regulating angiogenesis, FGF receptors (FGFR1-4) controlling cell proliferation and differentiation, EGF receptor family supporting epithelial cell growth, PDGF receptors modulating pericyte recruitment and vessel stabilization