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Role of Sphingolipids in Insulin Processing Increased circulating and intracellular lipids, such as diglycerides, cholesterol esters, and sphingolipids, has been implicated in causing effects in various tissues that, in combination, lead to the clinical manifestations of diabetes

In recent years, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as effective therapeutic agents, as they stimulate insulin secretion and suppress glucagon release in a glucose-dependent manner, thereby improving glycemic control with a low risk of hypoglycemia [2]