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10.1016/j.tips.2013.05.010 Trends Pharmacol

Jamier, C

NNMT methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor

This quick response occurs because the vitamin is rapidly absorbed into the bloodstream, offering fast relief from fatigue or brain fog, especially for those with deficiencies