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It is synthesized in the muscle tissue, lungs, and brain from glutamate through the enzyme glutamine synthetase

In addition, 4-hydroxyphenylacetic acid, gluconic acid and palmitic acid displayed a converse trend that enlarged in response to Asian ginseng and fell in response to American ginseng while glycerol 1-palmitate had an opposite tendency (Fig

Our findings are in line with other observations suggesting that the ligature induced experimental periodontitis is a useful and highly reproducible model for gingival/periodontal inflammation (41, 42)

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