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This complexity is further heightened by differences in adiponectin production between visceral and subcutaneous fat, notably with obesity-associated declines in adiponectin from subcutaneous sources [33]

The SURMOUNT trials show consistently greater weight loss with tirzepatide compared to semaglutide, but also steeper regain after discontinuation

Supplements to Support GLP-1 Medications While some supplements try to promise you the same benefits of, another overlookedbut more helpful categoryare supplements that can help ease the side effects that can come with prescription weight loss meds: Nutrient deficiencies: When you eat less in general, you may not be getting enough key vitamins and minerals through your diet Gastrointestinal issues: Nausea, bloating, and upset stomach are oft-cited side effects of GLP1s, which may result from slower stomach emptying (this helps you feel fuller longer but also may make you a bit uncomfortable in the process) These issues can be enough to stop using the medications, which can cause some people to abandon their weight loss journey

Some people can taper after 6-12 months, while others may need long-term treatment to maintain results