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Finally, the disruption of IGF-I/ECM association by glycosylation cannot not explain why there is an enrichment of glycosylated pro-IGF-I in muscle extracts 23

Less common but notable risks include: Gallbladder issues: Including gallstones, especially in rapid weight loss Pancreatitis: Rare, but a known risk with GLP-1 agonists Kidney function changes: Usually secondary to dehydration from vomiting Thyroid C-cell tumors: Observed in rodent studies, but not confirmed in humans Patients with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2) are typically not candidates for GLP-1 therapy

Data collection included patient-reported information collected via questionnaires, either online or on paper, with assistance from research staff and data extraction from electronic medical records