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Alla dose massima commerciale di 17,2 mg al giorno , orforglipron ha prodotto una perdita di peso media dell11,2% a 72 settimane, contro il 2,1% del placebo

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The case series published in SAGE Open Medical Case Reports showed that patients who maintained exercise protocols of 3 to 5 resistance training sessions per week while on GLP-1 therapy preserved lean mass successfully, with some even gaining muscle while losing fat