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Folic acid alone will not treat Vitamin B12 deficiency or prevent possible damage to the spinal cord

One trial used 2000 g/day vitamin B 12 and demonstrated a mean difference of 680 pg/mL (95% confidence interval 392.7 to 967.3) in favor of oral vitamin B 12

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There is no national screening program for haemoglobinopathies within Australia and as a result there is variability in testing, but identifying vulnerable populations is important 29 (Table 3)