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GLP-1 RAs significantly reduced the risk of MACE compared with placebo (hazard ratio [HR] 0.87, 95% confidence interval [CI] 0.770.98) in HF coexisting with T2DM

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Survodutide (BI 456906) is a GLP-1R/GCGR dual agonist developed by Boehringer Ingelheim, with outcomes of a phase 2 trial in MASLD and a phase 1 trial in cirrhosis published almost simultaneously with tirzepatide

When combined with expert guidance on injection site selection and technique, genetic insights can support a more informed conversation with your provider about dosing frequency, formulation choice (compounded semaglutide versus tirzepatide), and expected timelines for therapeutic response