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10.2174/138920211795860125 Rayapudi S, Schwartz SG, Wang X, Chavis P: Vitamin A and fish oils for retinitis pigmentosa

Akt is deactivated and Bcl-2-associated death promoter (BAD) phosphorylation is lost in one pathway due to a stalled survival pathway, whereas Fas cell surface death receptor (FAS) is upregulated through stimulation of c-Jun-N-terminal kinase, which activates caspase-8, phosphorylates Fas-associated protein with death domain (FADD), and truncates BH3-interacting domain death agonist (BID)

Therefore, it seems that MTs effect on both RAD51 and XRCC5 is primarily mediated through TRIP13 inhibition

iii) Autophagy may disrupt other mechanisms involved in CP nephrotoxicity, particularly apoptosis and oxidative stress