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This duration is based on the effective lifespan of the benzyl alcohol as a preservative under ideal conditions

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Although these findings highlight integrin inhibitors as a viable class of ECM-targeted therapeutics, the majority of candidates remain at the preclinical or early clinical stage, and unresolved issues-including off-target toxicity, uncertainties in dose optimization, and limitations in delivery strategies pose substantial barriers to successful clinical translation (174)

Altered adipose tissue, elevated adiponectin levels, changed ghrelin and oxytocin and irisin levels, GHD and impaired ANS all may play a role in lower insulin levels and in lower IR in PWS patients